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The vitamin D receptor gene FokI polymorphism: Functional impact on the immune system

✍ Scribed by Evelyne van Etten; Lieve Verlinden; Annapaula Giulietti; Elizabeth Ramos-Lopez; Dumitru D. Branisteanu; Gabriela B. Ferreira; Lut Overbergh; Annemieke Verstuyf; Roger Bouillon; Bart O. Roep; Klaus Badenhoop; Chantal Mathieu

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
323 KB
Volume
37
Category
Article
ISSN
0014-2980

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## Abstract The activity of β‐catenin, commonly dysregulated in human colon cancers, is inhibited by the vitamin D receptor (VDR), and this mechanism is postulated to explain the putative anti‐cancer activity of vitamin D metabolites in the colon. We investigated the effect of a common __Fok__I res