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The Virion Host Shutoff Function of Herpes Simplex Virus Type 1 Plays a Role in Corneal Invasion and Functions Independently of the Cell Cycle

✍ Scribed by Lisa Strelow; Tracy Smith; David Leib


Book ID
112271529
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
732 KB
Volume
231
Category
Article
ISSN
0042-6822

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The enzyme herpes simplex virus type 1 thymidine kinase (HSV1 TK) salvages thymidine into the DNA metabolism of the virus. In the active site, the thymine ring of the nucleoside binds in a pocket, formed by two residues, Tyr-172 and Met-128, in a sandwich-type orientation. To investigate the nature