The vinylogous Witkop cyclisation

✍ Scribed by Elena L. Ruchkina; Alexander J. Blake; Mark Mascal

• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 171 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)01760-8

✦ Synopsis

The first example of a vinylogous Witkop cyclisation produces a novel azonino [c,d]indole, a carbocyclic analogue of the tumour-promoting indolactam family of natural products. A similar reaction previously reported to give azecino [c,d]indoles leads only to azocino [c,d]indoles, even when the radical centre is stabilised by the presence of halogens.