The Variety of Human Virus Evolution
β Scribed by Walter M. Fitch
- Book ID
- 102976319
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 617 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1055-7903
No coin nor oath required. For personal study only.
β¦ Synopsis
There have been many wise suggestions of ways that evolution may occur but those ways seem often hard to support with good examples. Viruses have proven to be replete with some of these items. This paper reviews work that shows: (1) very fast rates of evolution; (2) positive Darwinian selection with the selective pressure specifically identified; (3) viral reassortment; (4) grossly unequal rates of evolution depending upon the host of the virus; (5) accurate dating of the cenancestor, the most recent common ancestor; (6) correspondence between the evolutionary tree and the geography of the place of isolation; (7) punctuated molecular evolution; and (8) network evolution.
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Population genetic and virological methods yield estimates for the mean replication rate of the Human Immunodeficiency Virus type 1 (HIV-1) that differ by six fold. I present a simple model that can reconcile the estimates obtained from each method by considering the role of intra-host population st