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The Variable Number of Tandem Repeats Polymorphism of the Dopamine Transporter Gene Is Not Associated with Significant Change in Dopamine Transporter Phenotype in Humans

✍ Scribed by Diana Martinez; Joel Gelernter; Anissa Abi-Dargham; Christopher H van Dyck; Lawrence Kegeles; Robert B Innis; Marc Laruelle

Book ID: 114280742
Publisher: Nature Publishing Group
Year: 2001
Tongue: English
Weight: 165 KB
Volume: 24
Category: Article
ISSN: 1470-634X
DOI: 10.1016/s0893-133x(00)00216-5

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## Abstract The presynaptic dopamine transporter in nigral dopaminergic neurons confers susceptibility to the cytotoxic effects of the neurotoxic metabolite of 1‐methy1‐4‐phenyl‐1,2,3,6‐tetrahydropyridine. Polymorphisms in the dopamine transporter might influence the susceptibility to such toxins.