✦ LIBER ✦

The value of tumour marker kinetics in the management of patients with primary hepatocellular carcinoma

✍ Scribed by Dr. P. K. Buamah; O. F. W. James; A. W. Skillen; A. L. Harris

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 241 KB
Volume: 37
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930370305

No coin nor oath required. For personal study only.

✦ Synopsis

Serum alpha-fetoprotein (AFP) has been measured during chemotherapy of ten patients with hepatocellular carcinoma. Whenever the AFP concentration of a sample was lower than that of the previous sample the apparent half-life (AHL) of the protein was calculated. The biological half-life of AFP is 5 days so that values in excess of this were indicative of continuing or increased synthesis and secretion of AFP. The AHL for AFP provided a means of assessing efficacy of treatment. Increases in AHL generally predicted a rise in serum AFP and give advance warning of the need to change therapy.

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