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The value of genetic polymorphisms to predict toxicity in metastatic colorectal patients with irinotecan-based regimens

✍ Scribed by Lamas, M. J.; Duran, G.; Balboa, E.; Bernardez, B.; Candamio, S.; Vidal, Y.; Mosquera, A.; Giraldez, J. M.; Lopez, R.; Carracedo, A.; Barros, F.

Book ID
111964955
Publisher
Springer
Year
2012
Tongue
English
Weight
279 KB
Volume
69
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND It is known that the uridine‐diphosphoglucuronosyl transferase 1A1 (UGT1A1)\*28 polymorphism reduces UGT1A1 enzyme activity, which may lead to severe toxicities in patients who receive irinotecan. This study was conducted to assess the influence of this polymorphism on th