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The vacuolar (H+)-ATPase: subunit arrangement and in vivo regulation

✍ Scribed by Jie Qi; Yanru Wang; Michael Forgac

Publisher
Springer US
Year
2007
Tongue
English
Weight
127 KB
Volume
39
Category
Article
ISSN
0145-479X

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Two distinct mechanisms have been shown to mediate cytoplasmic p H (pH,) recovery in acid-loaded peritoneal macrophages (M+s): Na+/H+ exchange and H + extrusion by vacuolar-type (V-type) H+ ATPases. The present studies examined the relative roles of these two systems in maintaining pH, and cell func