The utility of fluorescence in situ hybridization analysis in diagnosing myelodysplastic syndromes is limited to cases with karyotype failure

Loss of genetic material is more common

Loss of genetic material is more common than gain in acute myeloid leukemia with complex aberrant karyotype: A detailed analysis of 125 cases using conventional chromosome analysis and fluorescence in situ hybridization including 24-color FISH

✍ Claudia Schoch; Torsten Haferlach; Sabina Bursch; Daniela Gerstner; Susanne Schn 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 318 KB 👁 1 views

## Abstract Patients with acute myeloid leukemia (AML) and a complex aberrant karyotype have a poor outcome despite intensive antileukemic treatment. The aim of this study was to analyze in detail the genetic abnormalities in this subgroup of AML. Therefore, 125 AML cases with complex aberrant kary