The use of the simplex method for the optimisation of non-linear functions on a laboratory microcomputer
โ Scribed by R. Nicol; P. Smith; P.R. Raggatt
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 660 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0010-4825
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โฆ Synopsis
The use of the microcomputer
for the processing of analytical data in the laboratory is currently increasing. However, computational methods which have been used successfully on minicomputers may not be suitable for microcomputer implementation due to the lack of available precision. This paper describes a technique, namely the simplex method, which may be successfully applied to the processing of laboratory data on an 8-bit microcomputer.
The method is used to optimise a non-linear function in order to fit a curve to radioimmunoassay (RIA) and immunoradiometricassay (IRMA) data. The microcomputer package described has been tested on laboratory data and is currently in use in a clinical biochemistry laboratory.
Simplex method Non-linear curve fitting Radioimmunoassay Laboratory data processing Clinical biochemistry Immunoradiometricassay
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