The use of the N(?)-phenacyl group for the protection of the histidine side chain in peptide synthesis
โ Scribed by Fletcher, Andrew R.; Jones, John H.; Ramage, William I.; Stachulski, Andrew V.
- Book ID
- 121481549
- Publisher
- Royal Society of Chemistry
- Year
- 1979
- Weight
- 934 KB
- Volume
- 0
- Category
- Article
- ISSN
- 1472-7781
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๐ SIMILAR VOLUMES
The trltyl (Trt) group 1s ideally suited for the sjde-chain protection of His In peptide syntheses, in combination with 9-fluorenylmethyloxycarbonyl (Fmoc) In Na-and protecting groups cleavable by mild acidolysis in other poslt1ons of the peptide. 2,4,5-trlchlorophenyl (Tcp)-and pentafluorophenyl (P
In this communication we introduce a promising masking agent --the vinyloxycarbonyl or VOC group --for the protection of amino functions in peptide chemistry. Amino acids are easily converted to their N-VOC derivatives (l\_) in dilute aqueous base using the known vinyl chloroformate' in dioxane as t
Protection of the imidazole ring of the histidine residue is not required for the elongation of an oligonucleotide chain at the side chain hydroxyl group of an amino acid residue by the phosphite triester approach. For the assembly of the peptide chain, the 2,4-dinitrophenyl group is the best altern