‘The use of selective serotonin reuptake inhibitors for depression and psychosis complicating dementia’—1997, 12, 519–527

✍ Scribed by Brian Lawlor

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 55 KB
• Volume: 13
• Category: Article
• ISSN: 0885-6230
• DOI: 10.1002/(sici)1099-1166(199807)13:7<496::aid-gps789>3.0.co;2-t

✦ Synopsis

serotonin syndrome may have been caused by the sum of the serotonergic eects of mirtazapine and ¯uoxetine. The serotonin syndrome appeared despite the concurrent use of chlopromazine, which, by blocking 5-HT1/5-HT2 receptors, was reported to treat it . The same mirtazapine, by blocking 5-HT2/5-HT3 receptors, was reported to treat the serotonin syndrome . This suggests that the mirtazapine±¯uoxetine combination potently increased serotonin activity, and/or this patient had a marked sensitivity to serotonin, possibly age-related.