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The use of pulmonary function testing as a quantitative measurement for therapeutic trials

✍ Scribed by Robert C. Griggs

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 422 KB
Volume: 13
Category: Article
ISSN: 0148-639X
DOI: 10.1002/mus.880131310

No coin nor oath required. For personal study only.

✦ Synopsis

Pulmonary function tests are a quantitative measure of neuromuscular function and are therefore potentially important measurements for clinical trials. Since most patients with progressive neuromuscular disease develop restrictive lung disease, pulmonary function tests have been used in longitudinal studies of natural history and in clinical trials. Longitudinal and cross-sectional studies have been conducted in Duchenne muscular dystrophy (DMD),' myotonic dystrophy,2 and myasthenia g r a v i ~. ~

The appeal of pulmonary function tests is that they are critical in the recognition, prevention, and management of respiratory failure. In addition, they are easy to analyze in clinical trials because they are quantitated by linear as opposed to interval scales. The most frequently used measures are: (1) forced vital capacity, (2) one-second timed vital capacity, (3) maximum inspiratory pressure, (4) maximum expiratory pres-From the

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