The use of polyhedral oligomeric silsesquioxane (POSS) as a soluble support for organic synthesis: A case study with a POSS-bound isocyanate scavenger reagent

✍ Scribed by Mark York; Richard A. Evans

• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 310 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.07.015

✦ Synopsis

The use of polyhedral oligomeric silsesquioxane (POSS) as a soluble support for use in organic synthesis is reported. A POSS-bound isocyanate was readily synthesised in one step from commercially available starting materials and isolated in high yield and purity by simple filtration. It was found to perform well as a scavenger for excess amine in the solution phase synthesis of amides and sulfonamides, allowing product isolation in high yield and purity.