The use of partially porous particle columns for the routine, generic analysis of biological samples for pharmacokinetic studies in drug discovery by reversed-phase ultra-high performance liquid chromatography–tandem mass spectrometry

Demonstration of the capabilities of a p

Demonstration of the capabilities of a parallel high performance liquid chromatography tandem mass spectrometry system for use in the analysis of drug discovery plasma samples

✍ Walter A. Korfmacher; John Veals; Kimberly Dunn-Meynell; Xiping Zhang; Greg Tuck 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 102 KB 👁 3 views

There is a continuing need for increased throughput in the evaluation of new drug entities in terms of their pharmacokinetic (PK) parameters. This report describes an alternative procedure for increasing the throughput of plasma samples assayed in one overnight analysis: the use of parallel high per