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The use of microwave oven for the rapid hydrolysis of bile acid methyl esters

✍ Scribed by B. Dayal; G. Salen; V. Dayal

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
428 KB
Volume
59
Category
Article
ISSN
0009-3084

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✦ Synopsis

An efficient and convenient procedure for the hydrolysis of bile acid methyl esters is described. This is achieved by the addition of aqueous lithium hydroxide in methanol/dioxane/tetrahydrofuran (or dimethylformamide) in the microwave oven. Under these conditions the formates as well as the acetate derivatives prepared under microwave irradiation conditions were also hydrolyzed, and the desired bile acids were isolated in 86-94% yield. All these reactions were completed in the microwave oven within 45-60 s.

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Four different types of organic reactions have been studied and seven different organic compounds have been prepared, under pressure in a microwave oven. Considerable rate increases have been observed.