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The use of mammalian and bacterial cells to study the biotransformation of mutagens through extracts of rodent liver

✍ Scribed by G.R. Mohn; J. Ellenberger; J. Osterhoff

Book ID
119091552
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
140 KB
Volume
31
Category
Article
ISSN
0165-1161

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Mutagenic activity of cyclophosphamide,
Mutagenic activity of cyclophosphamide, ifosfamide, and trofosfamide in different genes of Escherichia coli and Salmonella typhimurium after biotransformation through extracts of rodent liver
✍ Ellenberger, J. ;Mohn, G. πŸ“‚ Article πŸ“… 1975 πŸ› Springer-Verlag βš– 712 KB

Experiments are performed to compare the mutagenic properties of the three phosphamide esters of nitrogen mustard, cyclophosphamide (CP), ifosfamide (IF), and trofosfamide (TF), in different bacterial systems. The systems include forward mutations leading to resistance against 5-methyltryptophan (MT