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The Use of Intermediates with Preformed Disulfide Bridge for the Synthesis of Oxytocin and Deamino-oxytocin

✍ Scribed by M. Mühlemann; M. I. Titov; R. Schwyzer; J. Rudinger


Book ID
102856389
Publisher
John Wiley and Sons
Year
1972
Tongue
German
Weight
554 KB
Volume
55
Category
Article
ISSN
0018-019X

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✦ Synopsis


Abstract

The disulfide‐bridged hexapeptides 6a and 6b have been prepared from benzyl‐protected intermediates. Coupling of 6a and 6b with prolyl‐leucyl‐glycine amide afforded deamino‐oxytocin (7a) and the protected oxytocin derivative 7b, respectively; the latter was converted to oxytocin (7c) by removal of the Boc protecting group.


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