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The Use of Inhibitors to Study Endocytic Pathways of Gene Carriers: Optimization and Pitfalls

โœ Scribed by Vercauteren, Dries; Vandenbroucke, Roosmarijn E; Jones, Arwyn T; Rejman, Joanna; Demeester, Joseph; De Smedt, Stefaan C; Sanders, Niek N; Braeckmans, Kevin


Book ID
121200439
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
596 KB
Volume
18
Category
Article
ISSN
1525-0016

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Use of enzyme inhibitors to evaluate the
โœ Gary Eichenbaum; Jennifer Skibbe; Andrew Parkinson; Mark D. Johnson; Dawn Baumga ๐Ÿ“‚ Article ๐Ÿ“… 2012 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 557 KB

An approach was developed that uses enzyme inhibitors to support the assessment of the pathways that are responsible for the conversion of intravenously administered ester and amide prodrugs in different biological matrices. The methodology was applied to ceftobiprole medocaril (BAL5788), the prodru