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The Use of Hydrogen Peroxide for Closing Disulfide Bridges in Peptides

✍ Scribed by M. V. Sidorova; A. S. Molokoedov; A. A. Az'muko; E. V. Kudryavtseva; E. Krause; M. V. Ovchinnikov; Zh. D. Bespalova

Book ID
111607363
Publisher
SP MAIK Nauka/Interperiodica
Year
2004
Tongue
English
Weight
79 KB
Volume
30
Category
Article
ISSN
1068-1620

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Hydrogen peroxide for disulfide bridge f
Hydrogen peroxide for disulfide bridge formation in methionine-containing peptides
✍ Elena V. Kudryavtseva; Mariya V. Sidorova; Mikhail V. Ovchinnikov; Zhanna D. Bes πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 142 KB πŸ‘ 1 views

Two methionine-containing peptides, endothelin 1 and the 1-16 fragment of the receptor of the plasminogen activator 1 for human urokinase, were synthesized and cyclized by hydrogen peroxide. Endothelin 1 was obtained by using regioselective and random schemes of disulfide bond formation. The conditi