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The use of high-resolution solid-state NMR spectroscopy and differential scanning calorimetry to study interactions of anaesthetic steroids with membrane

✍ Scribed by Thomas Mavromoustakos; Efthimia Theodoropoulou; De-Ping Yang


Book ID
117048723
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
346 KB
Volume
1328
Category
Article
ISSN
0005-2736

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Cyclosporin A (CyA) interacts with lipid membranes. Binding reaction and membrane location of CyA and analogs were examined with 2 H-NMR, high-sensitivity isothermal titration calorimetry (ITC), and CD spectroscopy. Effects of CyA and charged analogs on the phosphocholine head group and on the membr