The use of Gd-DTPA as a marker of myocardial viability in reperfused acute myocardial infarction
✍ Scribed by Raoul S. Pereira; Frank S. Prato; Gerald Wisenberg; Jane Sykes; Kenneth J. Yvorchuk
- Book ID
- 110308407
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 542 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1569-5794
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## Abstract The long‐lasting signal enhancement by Gd‐DTPA in areas of myocardial infarction has been conventionally explained by low perfusion and an enhanced Gd distribution volume. To test whether binding of Gd to myocardial constituents is an additional factor contributing to this effect, Gd‐DT
## Abstract Results of simulations are shown which illustrate how the concentration‐time curves of an extravascular extracellular (EVEC) contrast agent, such as Gd‐DTPA, vary in myocardial tissue. The simulations show that the variable permeability of dead myocytes within a recent myocardial infarc
## Abstract The potential of a phosphonate‐modified‐Gd‐DTPA for MR image enhancement of myocardial infarction has been demonstrated in imaging experiments on rats. The agent, 1‐hydroxy‐3‐aminopropane‐1, 1‐diphosphonate‐modified‐Gd‐DTPA (Gd‐DTPA‐HPDP) accumulates in two models of myocardial infarcti