𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The Use of Fluoride as a Leaving Group: SN2′ Displacement of a CF Bond on 3,3-Difluoropropenes with Organolithium Reagents To Give Direct Access to Monofluoroalkenes

✍ Scribed by Maxime Bergeron; Thomas Johnson; Prof. Jean-François Paquin

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
372 KB
Volume
123
Category
Article
ISSN
0044-8249

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

The Use of Fluoride as a Leaving Group:
The Use of Fluoride as a Leaving Group: SN2′ Displacement of a CF Bond on 3,3-Difluoropropenes with Organolithium Reagents To Give Direct Access to Monofluoroalkenes
✍ Maxime Bergeron; Thomas Johnson; Prof. Jean-François Paquin 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 354 KB

Typical procedure: A solution of nBuLi (2.6 m in hexanes, 0.33 mmol) was slowly added to a solution of 1 (50 mg, 0.28 mmol) in THF (2.5 mL) at À78 8C. The mixture was stirred for 2 h before being quenched with drops of water. The mixture was poured into saturated aqueous NaHCO 3 and extracted with E