The Use of Endothelial Progenitor Cells for Prevascularized Bone Tissue Engineering
β Scribed by Rouwkema, Jeroen; Westerweel, Peter E.; de Boer, Jan; Verhaar, Marianne C.; van Blitterswijk, Clemens A.
- Book ID
- 120155088
- Publisher
- Mary Ann Liebert
- Year
- 2009
- Tongue
- English
- Weight
- 931 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1937-3341
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## Abstract In addition to a biocompatible scaffold and an osteogenic cell population, tissueβengineered bone requires an appropriate vascular bed to overcome the obstacle of nutrient and oxygen transport in the 3D structure. We hypothesized that the addition of endothelial cells (ECs) may improve
## Abstract For successful tissue engineering, neovascularization of the implanted tissue is critical. Factors generated by endothelial cells are also considered crucial for the process of osteogenesis. The direct effects of supplementing tissue engineered constructs with cultured endothelial proge
## Abstract Thrombosis and intimal hyperplasia limit the usefulness of small caliber vascular grafts. While some improvements have been reported for grafts seeded with mature endothelial cells (EC), the harvesting of ECs from autologous sources, for example, veins or adipose tissue, remains problem