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The use of drugs which deplete intracellular glutathione in hypoxic cell radiosensitization

โœ Scribed by Edward A. Bump; Ning Y. Yu; J.Martin Brown


Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
417 KB
Volume
8
Category
Article
ISSN
0360-3016

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## Abstract A major limitation to the clinical usefulness of cancer chemotherapy is the onset of acquired drug resistance, in which the effectiveness of a drug such as Doxorubicin (DOX), used in a wide variety of neoplasms, diminishes following repeated administration. Resistance is associated with