Use of enzyme inhibitors to evaluate the
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Gary Eichenbaum; Jennifer Skibbe; Andrew Parkinson; Mark D. Johnson; Dawn Baumga
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Article
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2012
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John Wiley and Sons
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English
β 557 KB
An approach was developed that uses enzyme inhibitors to support the assessment of the pathways that are responsible for the conversion of intravenously administered ester and amide prodrugs in different biological matrices. The methodology was applied to ceftobiprole medocaril (BAL5788), the prodru