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The use of cell lines for the study of Waldenström's macroglobulinemia

✍ Scribed by Morie Gertz; Stephen Ansell

Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
68 KB
Volume
32
Category
Article
ISSN
0145-2126

No coin nor oath required. For personal study only.

✦ Synopsis

In this issue of Leukemia Research, Drexler and MacLeod raise questions about the origins of cell lines used in the study of Waldenström's macroglobulinemia and suggest caution in the use of these cell lines as models of this disease [Drexler HG, Macleod RAF. Malignant hematopoietic cell lines: in vitro models for the studies of Waldenström's macroglobulinemia. Leuk Res 2008].

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Waldenström macroglobulinemia may be said to be characterized cheifly by two features: (1) a striking increase in IgM globulin of the "monoclonal gammapathy" type and (2) an abnormal bone marrow characterized by either a leukemic or leukemic-like picture, in which lymphocytes of various types are pr