The use of boron tribromide as a catalyst for the rapid tritium labeling of aromatic compounds

✍ Scribed by John L. Garnett; Mervyn A. Long; Christopher A. Lukey

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: French
• Weight: 245 KB
• Volume: 22
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580220702

✦ Synopsis

Boron t r i b r o m i d e has been assessed as a c a t a l y s t f o r r a p i d t r i t i u m l a b e l i n g o f organic compounds using t r i t i a t e d water under m i l d conditions. A1 k y l and halogen s u b s t i t u t e d aromatics l a b e l e d r a p i d l y , t h e l a b e l i n g being most pronounced i n t h e o r t h o and para p o s i t i o n s . Compounds c o n t a f n i n g e l e c t r o p h i l i c d e a c t i v a t i n g groups were found t o be d i f f i c u l t t o l a b e l . Very 1 i t t l e byproduct formation was observed.