The use of antibodies against the IL-2 receptor in transplantation

✍ Scribed by Thomas A Waldmann; John O'Shea

• Book ID: 104358935
• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 638 KB
• Volume: 10
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(98)80215-x

✦ Synopsis

Humanized monoclonal antibodies that recognize the alpha chain of the IL-2 receptor (e.g. daclizumab) have been used to prevent allograft rejection, since this chain is expressed by T cells participating in allograft rejection but not by resting T cells. In a randomized trial, when added to standard cyclosporin-based immunosuppression, daclizumab significantly reduced the frequency of acute rejection of renal transplants.