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The use of an “internal standard” for control of the recovery in microdialysis

✍ Scribed by Carina Ingvast Larsson

Book ID
118344684
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
427 KB
Volume
49
Category
Article
ISSN
0024-3205

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One of the crucial issues in quantitative microdialysis is the reliability of recovery estimates to correctly estimate unbound drug tissue concentrations. If a deuterated calibrator is used for retrodialysis, the calibrator has the same properties as the study drug. However, recovery of the calibrat