## Abstract Synthesis of 4‐hydroxyindole labeled with ^14^C at the 2‐position was accomplished based on the vicarious nucleophilic substitution reaction of benzyl‐protected 3‐nitrophenol with __p__‐chlorophenoxyacetonitrile‐[1‐^14^C]. This was followed by the reductive cyclization of __o__‐nitrocya
The use of [5− 14C] meldrum's acid as a versatile intermediate in the synthesis of labelled 1,4-dihydropyridines
✍ Scribed by D.J. Wilkinson
- Publisher
- Elsevier Science
- Year
- 1988
- Weight
- 76 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0883-2889
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📜 SIMILAR VOLUMES
## Abstract A simple, high‐yielding synthesis of dibutyl[^14^C]formamide ([^14^C]DBF; **1**) from ^14^CO~2~ was developed (__Scheme 1__): reaction of LiBEt~3~H and ^14^CO~2~ followed by aqueous workup gave H^14^CO~2~H in high yield. Conversion of the [^14^C]formic acid to **1** was effected by a st
## Abstract For Abstract see ChemInform Abstract in Full Text.
The title compound, CGS 148248, was synthesized with a '%-label in the azepine ring in 14 steps starting with l-bromo-3-phenylpropane (1> and K1%N in an overall yield of 1.31%. The reaction of I with K 1 k N yielded the nitrile 2 which upon hydrolysis followed by ring closure gave a-tetral~ne-l-~~c