The Use of 13C–NMR. Spectroscopy in Biosynthetic Studies. II[1]. Biosynthesis of narasin, a new polyether ionophore from fermentation of Streptomyces aureofaciens [2]
✍ Scribed by Douglas E. Dorman; Jonathan W. Paschal; Walter M. Nakatsukasa; Lyell L. Huckstep; Norbert Neuss
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- German
- Weight
- 578 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
The labeling of the polyether ionophore, narasin, using ^13^C‐labeled acetate, propionates, and butyrates in the course of fermentation of Streptomyces aureofacies resulted in the isolation of differently labeled compounds. A careful examination of the ^13^C‐NMR. spectral data indicated derivation of narasin from five acetate, seven propionate, and three butyrate units. The evidence of indirect incorporation of ^13^C led to the first documented demonstration of conversion of propionate to butyrate in the course of the synthesis of narasin by S. aureofaciens.