𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The urinary excretion of corticosteroid sulfates by cancer patients

✍ Scribed by D. P. Rose; W. E. Fahl; L. Liskowski

Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
324 KB
Volume
36
Category
Article
ISSN
0008-543X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Urinary excretions of free cortisol and corticosteroid sulfates were determined in 31 female controls, 77 breast cancer patients, 14 cases of colonic cancer, and 7 patients with bronchial carcinoma. Elevated corticosteroid sulfate excretion was present in38% of patients with locally recurrent breast cancer and 30% of those with distant metastases, but in only 13% of the β€œearly” breast cancer cases. A similar abnormality was seen in colonic cancer. Urinary free cortisol was usually normal. ACTH stimulation in a normal subject produced marked increases of both urinary free cortisol and corticosteroid sulfates. It is concluded that elevated corticosteroid sulfate excretion in cancer patients arises from an increased cortisol production rate combined with increased sulfurylation of the steroid. In bronchial carcinoma patients, changes similar to those occurring in the ACTH–treated normal subject may have resulted from ectopic ACTH production in the tumor.

πŸ“œ SIMILAR VOLUMES

Urinary excretion of DOPA and metabolite
Urinary excretion of DOPA and metabolites by patients with melanoma
✍ Mary L. Voorhess πŸ“‚ Article πŸ“… 1970 πŸ› John Wiley and Sons 🌐 English βš– 298 KB πŸ‘ 2 views

In a n attempt to define a biochemical test which would be helpful in the care of individuals with malignant melanoma, urinary excretion of DOPA, homovanillic acid, dopamine, norepinephrine, epinephrine, and 3-methoxy-4-hydroxymandelic acid of 16 patients with advanced disease was measured. Abnormal

Biliary and urinary excretion of sulfate
Biliary and urinary excretion of sulfated, glucuronidated and tetrahydroxylated bile acids in cirrhotic patients
✍ Adolf Stiehl; Richard Raedsch; Gerda Rudolph; Ursula Gundert-Remy; Martin Senn πŸ“‚ Article πŸ“… 1985 πŸ› John Wiley and Sons 🌐 English βš– 436 KB

In patients with hepatobiliary diseases, considerable amounts of sulfated and glucuronidated bile acids are excreted in urine. Information on the biliary excretion of these compounds is lacking. We used an intestinal perfusion method to determine the biliary excretion of sulfated and glucuronidated

Excretion pattern investigation of urina
Excretion pattern investigation of urinary normal and modified nucleosides of breast cancer patients by RP-HPLC and factor analysis method
✍ G. Xu; H. R. Schmid; X. Lu; H. M. Liebich; P. Lu πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 83 KB πŸ‘ 2 views

Modified nucleosides, formed post-transcriptionally in RNA by a number of modification enzymes, are excreted in abnormal levels in the urine of patients with malignant tumors. To test their usefulness as tumor markers, and to compare them with the conventional tumor markers, a reversed-phase high-pe