The uracil permease ofSchizosaccharomyces pombe: A representative of a family of 10 transmembrane helix transporter proteins of yeasts

✍ Scribed by de Montigny, J.; Straub, M. L.; Wagner, R.; Bach, M. L.; Chevallier, M. R.

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 306 KB
• Volume: 14
• Category: Article
• ISSN: 0749-503X
• DOI: 10.1002/(sici)1097-0061(199808)14:11<1051::aid-yea287>3.0.co;2-1

✦ Synopsis

The uracil permease gene of Schizosaccharomyces pombe was cloned and sequenced. The deduced protein sequence shares strong similarities with five open reading frames from Saccharomyces cerevisiae, namely the uracil permease encoded by the FUR4 gene, the allantoin permease encoded by DAL4, a putative uridine permease (YBL042C) and two unknown ORFs YOR071c and YLR237w.

A topological model retaining ten transmembrane helices, based on predictions and on experimental data established for the uracil permease of S. cerevisiae by Galan and coworkers (1996), is discussed for the four closest proteins of this family of transporters. The sequence of the uracil permease gene of S. pombe has been deposited in the EMBL data bank under Accession Number X98696. 1998 John Wiley & Sons, Ltd.