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The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer’s disease

✍ Scribed by Stutzbach, Lauren D; Xie, Sharon X; Naj, Adam C; Albin, Roger; Gilman, Sid; Lee, Virginia M Y; Trojanowski, John Q; Devlin, Bernie; Schellenberg, Gerard D

Book ID
120893133
Publisher
Springer (Biomed Central Ltd.)
Year
2013
Tongue
English
Weight
838 KB
Volume
1
Category
Article
ISSN
2051-5960

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✍ D. M. A. Mann; R. Oliver; J. S. Snowden 📂 Article 📅 1993 🏛 Springer-Verlag 🌐 English ⚖ 717 KB

The topographic distribution of brain atrophy was quantified by image analysis of fixed coronal brain slices from 12 patients dying with Huntington's disease (HD) and from 4 other patients dying with progressive supranuclear palsy (PSP). In HD, atrophy was maximal within the caudate nucleus, putamen