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The unequivocal determination of in vivo lactic acid using two-dimensional double-quantum coherence-transfer spectroscopy

✍ Scribed by Christopher H Sotak; Dominique M Freeman; Ralph E Hurd

Publisher
Elsevier Science
Year
1988
Weight
458 KB
Volume
78
Category
Article
ISSN
0022-2364

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A volume-localized, two-dimensional NMR method which unambiguously measures lactate protons in the presence of interfering lipid resonances is presented. This technique employs the stimulated echo method for spatial selection and was used to observe lactic acid levels in a subcutaneously implanted R