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The UMD TP53 database and website: update and revisions

✍ Scribed by Dalil Hamroun; Shunsuke Kato; Chikashi Ishioka; Mireille Claustres; Christophe Béroud; Thierry Soussi

Book ID
102259244
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
346 KB
Volume
27
Category
Article
ISSN
1059-7794

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✦ Synopsis

Mutation of the p53 gene is the most frequent genetic alteration found in human cancer, but it is also the most frequently reported with more than 22,000 mutations published in 2,000 papers. In 1991, we developed a database and software to handle and analyze all this information. The database has been widely used for clinical analysis and molecular epidemiology. We have expanded the scope of the database by integrating structural, phylogenetic and biological information on wild-type (wt) and mutant TP53. Integration of the TP53 mutant activity database provides unique information that will be useful to both clinicians and scientists. All of this information is available from a new website (www.umd.be:2072/) that will generate a detailed informative page for every TP53 mutant in the database. New tools to check TP53 mutations and minimize errors found in the literature are also available.

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