## Background: The bone destruction in myeloma patients is largely responsible for the clinical features of the disease. however, only recently has attention focused on identifying and developing drugs targeted specifically at the osteolysis. receptor activator of nf-kappab ligand (rankl), macropha
The ubiquitin-proteasome pathway and enhanced activity of NF-κB in gastric carcinoma
✍ Scribed by Lingfei Wu; Zejin Pu; Jialin Feng; Guoping Li; Zhichao Zheng; Wenlv Shen
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 171 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Recent studies have demonstrated that increased expression of coding region determinant‐binding protein (CRD‐BP) in response to β‐catenin signaling leads to the stabilization of β‐TrCP1, a substrate‐specific component of SCF E3 ubiquitin ligase complex, resulting in an accelerated degra
## Abstract The Notch pathway is implicated in many aspects of the central nervous system (CNS) development and functions. Recently, we and others identified the Notch pathway to be involved in inflammatory events of the CNS. To understand the implication of this pathway on astrocytes, we have stud
## Abstract IL‐4 plays a pivotal role in the development of the Th2 cell mediated humoral immune response and causes IgE‐dependent allergic inflammatory diseases. Expression of IL‐4 in differentiated Th2 cells is regulated by transcription factors such as NF‐AT, AP‐1 and NF‐IL6. Recently, increasin
## Abstract Apoptosis is an endogenous process that can be a useful anti‐cancer tool. This study aimed to investigate the effect of Cl‐IB‐MECA, adenosine receptor A3 agonist, on TRAIL‐induced apoptosis of thyroid carcinoma cells. Cl‐IB‐MECA enhanced TRAIL‐mediated apoptosis in FRO but not in ARO ce