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The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

✍ Scribed by Lars Vereecke; Rudi Beyaert; Geert van Loo


Book ID
116578023
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
406 KB
Volume
30
Category
Article
ISSN
1471-4906

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## Abstract Inappropriate nuclear factor (NF) ΞΊB activity is one major hallmark of B‐cell malignancies and chronic lymphocytic leukemia (CLL). NFΞΊB‐dependent genes are involved in antiapoptosis, cell proliferation and metastasis and are responsible for survival and proliferation of tumors. However,