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The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs

โœ Scribed by Heiko Neuss; Xiaohua Huang; Bettina K. J. Hetfeld; Rupal Deva; Petra Henklein; Santosh Nigam; Julian W. Mall; Wolfgang Schwenk; Wolfgang Dubiel


Publisher
Springer
Year
2007
Tongue
English
Weight
490 KB
Volume
85
Category
Article
ISSN
0946-2716

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## Abstract Previous work showed a genetic control of cell cycle deregulation during hepatocarcinogenesis. We now evaluated in preneoplastic lesions, dysplastic nodules and hepatocellular carcinoma (HCC), chemically induced in genetically susceptible F344 and resistant Brown Norway (BN) rats, the r