The tyrosine kinase connection: how GPI-anchored proteins activate T cells

✍ Scribed by Deborah Brown

• Book ID: 103972953
• Publisher: Elsevier Science
• Year: 1993
• Tongue: English
• Weight: 888 KB
• Volume: 5
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/0952-7915(93)90052-t

✦ Synopsis

How can crosslinking of cell-surface glycosylphosphatidylinositol-anchored proteins activate T cells when the proteins do not reach the cytosol? Recent results show that glycosylphosphatidylinositol-anchored proteins associate with tyrosine kinases of the src family. Kinase activity is stimulated when glycosylphosphatidylinositol-anchored proteins are crosslinked. How the proteins are linked across the membrane, however, remains an intriguing mystery.