The tyrosinase activity of melanosomes from the harding-passey melanoma: The absence of a peroxidase component in vitro
β Scribed by R.Allan Mufson
- Book ID
- 115702768
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- English
- Weight
- 481 KB
- Volume
- 167
- Category
- Article
- ISSN
- 0003-9861
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π SIMILAR VOLUMES
The drug p-hydroxyanisole (OHA) was found to inhibit the incorporation of 3H-thymidine in the Harding-Passey melanoma cells in culture. Because the cultured cells had lost some of their pigment-forming capacity, the enzyme tyrosinase was added to the culture. This greatly increased the sensitivity o
## Abstract Tyrosinase is the rate limiting enzyme critically associated with melanin synthesis. The melanosomes are specialized membraneβbound organelles within melanocytic cells in which melanin polymers are ultimately deposited. To determine whether tyrosinase correlates with the number of melan