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The type of mutation in the low density lipoprotein receptor gene influences the cholesterol-lowering response of the HMG-CoA reductase inhibitor simvastatin in patients with heterozygous familial hypercholesterolaemia

✍ Scribed by Karen E Heath; Vilmundur Gudnason; Steve E Humphries; Mary Seed


Book ID
119438282
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
190 KB
Volume
143
Category
Article
ISSN
0021-9150

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Lipid-lowering response of the HMG-CoA r
✍ Luis A. Salazar; Mario H. Hirata; Γ‰der C.R. QuintΓ£o; Rosario D.C. Hirata πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 63 KB πŸ‘ 2 views

Although the efficacy of fluvastatin (HMG-CoA reductase inhibitor) in the treatment of primary hypercholesterolemia is well documented, a wide interindividual variation treatment response has been observed. We have studied the possible role of the AvaII (exon 13), HincII (exon 12), and PvuII (intron