Collagen type I selectively activates ec
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Barbara E. Slack; Marina S. Siniaia; Jan K. Blusztajn
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Article
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2006
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John Wiley and Sons
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English
β 454 KB
π 1 views
## Abstract The discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that is highly expressed in breast carcinoma cells. Upon binding to collagen, DDR1 undergoes autophosphorylation followed by limited proteolysis to generate a tyrosine phosphorylated Cβterminal fragment (CTF). Although