The two-receptor system PAR-1/PAR-4 mediates α-thrombin-induced [Ca2+]imobilization in human astrocytoma cells

Ca2+ mobilization mediated by transient

Ca2+ mobilization mediated by transient receptor potential canonical 3 is associated with thrombin-induced morphological changes in 1321N1 human astrocytoma cells

✍ Kenji Nakao; Hisashi Shirakawa; Aiko Sugishita; Ikkei Matsutani; Tetsuhiro Niido 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 544 KB

## Abstract Activated astrocytes show various patterns of Ca^2+^ mobilization under pathological conditions. In the present study we revealed a novel function of astrocytic Ca^2+^ dynamics through investigation of thrombin‐induced unique Ca^2+^ entry. Using 1321N1 human astrocytoma cells, which hav