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The tumor suppressor p33ING1b upregulates p16INK4a expression and induces cellular senescence

โœ Scribed by Na Li; Qian Li; Xiaoxiao Cao; Ganye Zhao; Lixiang Xue; Tanjun Tong


Book ID
113622729
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
681 KB
Volume
585
Category
Article
ISSN
0014-5793

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Primary cultured mouse hepatic cells become senescent within a short period, although rare cells form colonies from which continuously proliferating cell lines can be established. In contrast, hepatic tumor (HT) cells show little senescence and higher colony-forming capacity. To assess this differen