## Abstract In some respects, the EGFR appears to be an attractive target for tumor‐targeted antibody therapy: it is overexpressed in many types of epithelial tumor and inhibition of signaling often induces an anti‐tumor effect. The use of EGFR specific antibodies, however, may be limited by uptake
✦ LIBER ✦
The tumor-specific de2–7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR
✍ Scribed by Luwor, Rodney B; Zhu, Hong-Jian; Walker, Francesca; Vitali, Angela A; Perera, Rushika M; Burgess, Antony W; Scott, Andrew M; Johns, Terrance G
- Book ID
- 110068937
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 275 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0950-9232
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## Abstract ## BACKGROUND. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) have demonstrated clinical benefit in patients with nonsmall cell lung cancer (NSCLC), particularly those with tumors that have EGFR‐TK domain mutations. Moreover, the EGFR and cyclooxygenase (COX)‐2
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