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The tryptophan/histidine interaction in α-helices

✍ Scribed by Juan Fernández-Recio; Ana Vázquez; Concepción Civera; Paz Sevilla; Javier Sancho


Book ID
115628006
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
76 KB
Volume
270
Category
Article
ISSN
0022-2836

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## Abstract The oxygen of a peptide bond has two lone pairs of electrons. One of these lone pairs is poised to interact with the electron‐deficient carbon of the subsequent peptide bond in the chain. Any partial covalency that results from this n→π\* interaction should induce pyramidalization of th