The Trypanosoma cruzi membrane glycoprotein AGC10 inhibits human lymphocyte activation by a mechanism preceding translation of both, interleukin-2 and its high-affinity receptor subunits

Inhibitory effects of the Trypanosoma cr

Inhibitory effects of the Trypanosoma cruzi membrane glycoprotein AGC10 on the expression of IL-2 receptor chains and secretion of cytokines by subpopulations of activated human T lymphocytes

✍ Felipe Kierszenbaum; Juana L. de Diego; Manuel Fresno; Marcelo B. Sztein 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 145 KB 👁 2 views

The Trypanosoma cruzi membrane glycoprotein AGC10 has been shown to alter some human macrophage functions (De Diego, J. L. et al., J. Immunol. 1997. 159: 4983-4989). We show here that, in the presence of AGC10, [ 3 H]thymidine incorporation by normal human lymphocytes stimulated with anti-CD3 or phy