The “triamino-analogue” of methyl cholate; a facial amphiphile and scaffold with potential for combinatorial and molecular recognition chemistry

✍ Scribed by Shay Broderick; Anthony P Davis; Robert P Williams

• Book ID: 104259666
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 224 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01254-4

✦ Synopsis

The triamino steroid 2 is synthesized from cholic acid (1), and found to possess little tendency to aggregate at pH 5 -6 in aqueous solution. 2 and/or related derivatives are expected to find use in the synthesis of receptors and combinatorial libraries, and as "contrafacial amphiphiles" for drug delivery across cell membranes.